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KMID : 0358819910180040597
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Journal of Korean Society of Plastic and Reconstructive Surgeons
1991 Volume.18 No. 4 p.597 ~ p.602
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EXPERIMENTAL STUDY OF THE INTIMAL CHANGE AFTER MICROVASCULAR RECONSTRUCTION USING POLYURETHANE COMPOSITE MICROVASCULAR GRAFT
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Abstract
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Rapid endothelization is one of the most important factor in the success of microvascular prostheses. Intimal hyper- or hypoplasia can contribute to occlude the reconstructed vessel. Expanded polytetrafluoroethylene(ePTEE) artificial vessels have been used for replacement of the major arteries, but lack of endothelization has made them occluded. Senior author has reconstructed rat femoral veins successfully using non -biodegradable polyurethane-siliconeheparin composite microvascular prostheses. Purpose of this study was to evaluate the intimal change after reconstruction of rat femoral veins with poyurethane composite graft.
As time goes by, there were continuous, even growth of the endothelial cells. Ratios of the thickness of intima and graft(I/G ratio) were 0.9833±0.3408 at 4th week, 1.1683±0.3860 at 12th week and 0.7867±0.3655 at 24th week. There were no significant difference in I/G ratios between 4th week and 12th week and between 4th week and 24th week(p>0.05). However, there was significant difference in I/G ratio between 12th week and 24th week(p<0.05).
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KEYWORD
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